Crossresistance between Tuberactinomycin-N, Capreomycin and Kanamycin of <i>Mycobacterium tuberculosis</i> isolated from patients with pulmonary tuberculosis

Bai, Gill Han; Kim, Sang Jae

doi:1984.31.4.165

Tuberc Respir Dis > Volume 31(4); 1984 > Article

Original Article

Tuberculosis and Respiratory Diseases 1984;31(4):165-170.
DOI: https://doi.org/10.4046/trd.1984.31.4.165 Published online December 1, 1984.

Crossresistance between Tuberactinomycin-N, Capreomycin and Kanamycin of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis

Gill Han Bai, Sang Jae Kim

Korean lnstilule of Tuberculosis, Korean National Tuberculosis Association

항결핵제 Tuberactinomycin-N의 Capreomycin과 Kanamycin에 대한 교차내성 시험

배길한, 김상재

Abstract

Three hundred and thirty three strains of M. tuberculosis isolated from patients with pulmonary tuberculosis who had no history of chemotherapy were completely inhibited at 50 mcg/ ml of Tuberactinomycin-N and 98% or more strains, at 25 mcg/ ml in LöwensteinJensen medium. Of 183 strains from patients treated with KM for more than 6 months, 63 strains(34.4%) were resistant at 100 mcg/ ml of KM. Of those KM resistant strains, 53(84.1 %) were resistant to CPM while only 3 strains(4.8% ) were resistant to TUM-N. The drug susceptibility pattern of 2,759 strains from patients whose chemotherapy history were not known indicated considerable cross-resistance between TUM-N and CPM and one-way cross-resistance from KM to CPM, meanwhile cross-resistance from TUM-N or CPM to 'KM were not significant.