Tuberc Respir Dis > Volume 32(1); 1985 > Article
Tuberculosis and Respiratory Diseases 1985;32(1):46-53.
DOI: https://doi.org/10.4046/trd.1985.32.1.46    Published online March 1, 1985.
Angiotensin Converting Enzyme in Human Adult Respiratory Distress Syndrome
Dong Cheol Han1, Dong Ho Yang1, Tae Jun Kim1, Sung Gyu Hwang1, Choon Sik Park1, Hyun Ho Kong2, Young Soo Sim2, Yong Chul Han2
1Department of Internal Medicine, Soon Chun Hyang University, School of Medicine, Seoul, Korea
2Department of Internal Medicine, Seoul National university, Collge of Medicine, Seoul, Korea
성인성 호흡장애 증후군에서의 angiotensin converting enzyme
한동철1, 양동호1, 김태준1, 황성규1, 박춘식1, 공헌호2, 심영수2, 한용철2
Abstract
Angiotensin converting enzyme (ACE) is almost entirely derived from pulmonary endothelium and the activity of ACE could be used as an index of the pulmonary endothelial damage. We measured the ratio of arterial oxygen partial pressure to inspired oxygen fraction(PaO2/FiO2) and serum ACE levels in 16 patients with adult respiratory distress syndrome (ARDS) daily from day 1 to 7 on ventilator to study correlation between ACE and PaO2/FiO2 and the predictive value of ACE in 7 patients with sepsis and 7 patients with high pressure edema and to study value of ACE in the differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema. Our data is shown: Serum ACE and PaO2/FiO2 were not correlated(r = - 0.04, P> 0.1 ). The result of this study suggests that serum ACE level may be useful in differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema but have no prognostic value in predicting survival or death of a patient with ARDS.


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