Tuberc Respir Dis > Volume 33(1); 1986 > Article
Tuberculosis and Respiratory Diseases 1986;33(1):43-50.
DOI: https://doi.org/10.4046/trd.1986.33.1.43    Published online March 1, 1986.
Effect of Smoking on Secretory IgA in Bronchoalveolar Lavage Fluid
I. H. Kim, C. H. Kim, D. H. Yang, S. Y. Ahn, C. S. Park
Department of Internal Medicine, Soon Chun Hyang University Hospital, Seoul, Korea
흡연에 의한 기관지폐포 세척액 내의 분비형 IgA의 동향
김인호, 김치환, 양동호, 안상용, 박춘식
Abstract
Synthesis of S-IgA in bronchial tree is dependent on the epithelial cell function, which could be influenced by smoking. To evaluate the effect of smoking on bronchial epithelium and the value of S-IgA to differentiate malignancy from benign lung diseases, S-IgA was measured in the bronoalveolar lavage fluid of 34 patients with lung cancer and pulmonary tuberculosis. The results were as follows: 1) S-IgA concentration of BAL fluid is 2.61± 1.93 flg/m1 in smokers compared with 5.26 ±3.66 μg/ml in nonsmokers(p<0.025). 2) There was no difference of S-IgA concentration in BAL fluid not only between cancer-smoker group and tuberculosis-smoker group but also between cancer-nonsmoker group and tuberculosis-nonsmoker group. 3) Serum S-IgA concentration of smokers is not different from that of nonsmoker. 4) The ratio of S-IgA to albumin in BAL fluid to S-IgA to albumin in serum is above 1.0 in all cases and that smokers is not different from that of nonsmokers. In conclusion, the smoking causes S-IgA synthesis in bronchial tree to diminish and S-IgA measurement in serum and BAL fluid have no diagnostic value to differentiate malignant disease from Benign lung disease.


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