Tuberc Respir Dis > Volume 34(2); 1987 > Article
Tuberculosis and Respiratory Diseases 1987;34(2):137-143.
DOI: https://doi.org/10.4046/trd.1987.34.2.137    Published online June 1, 1987.
Relapse Rates within One Year after the Completion of Treatment with Short Course Cemotherapy for Pulmonary Tuberculosis Under Programme Conditions
Sung Chill Chang, Yong Man Yoon, Young Pyo Hong
Korean Institute of Tuberculosis, The Korean National Tuberculosis Association
폐결핵에 대한 9개월 및 6개월 단기치료종결 일년이내의 재발률
장승칠, 윤용만, 홍영표
Abstract
The relapse rate within one year after the completion of a six-month regimen (2HERZ/4HER) with initial two months supplementation of pyrazinamide was compared with that of the current 9 month regimen (9HER). A total of 673 microscopy positive pulmonary tuberculosis patients were admitted and randomly allocated to each regimen (351 to 9HER and 322 to 2HERZ/ 4HER) at 13 Health Centres in the Chunchongbuk-do province during the period of one year and three months from October 1983 through December 1984. 18 patients were excluded from main analyses, because of various pretreatment conditions. Seventy-five (22.0%) of 341 9HER patients and 57(18.2%) of 314 2HERZ/ 4HER had dropped out because of various reasons. 1n 9HER regimen, 255 patients (74.8%) attained a bacteriologically favourable status and .4 (1.2%) failed. The results were not available in 7 patients(2.1% ) due to lack of fol1ow-up examinations toward the end of the treatment. And in 2HERZ/4HER, 248 patients (79.0%) achieved a bacteriological1y favourable response, 1(0.3%) failed and 8(2.5%) were unknown. Out of those who achieved a bacteriologically favourable status, 12 have bacteriological1y relapsed in 9HER and 9 in 2HERZ/4HER within one year after the termination of the short course regimens. The relapse rates calculated by Life Table Method were 5.3% and 4.3% in 9HER and 2HERZ/ 4HER respectively. There was no significant difference in relapse rates between the two groups (p > 0.05). It was concluded that the efficiency of the six-month short course regimen so far would be similar to the nine-month regimen.


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