Tuberc Respir Dis > Volume 35(3); 1988 > Article
Tuberculosis and Respiratory Diseases 1988;35(3):210-215.
DOI:    Published online September 1, 1988.
A Case of Diffuse Alveolar Hemorrhage Associated with Overlap syndrome
Ho Kee Yum, Hong Ok Ryoo, Dong Soon Kim
Department of lnternal Medicine, Seoul Paik Hospital InJe Medical College, Seoul, Korea
동반증후군(Overlap Syndrome)에 합병된 미만성 폐포출혈 1예
염호기, 류홍옥, 김동순
Respiratory system is frequentl y involved in various connective tissue diseases. Pleural effusion, interstitial fibrosis, pulmonary vasculitis, and pneumonia are well known pulmonary manifestations. Diffuse intra-alveolar pulmonary hemorhage with or without hemoptysis is also a relatively common finding at the autopsy of systemic lupus erythematosus patients. But there was no report of pulmonary hemorrhage associated with connective tissue disease in Korea Recently we experienced a case with overlap syndrome (rheumatoid arthritis, systemic lupus erythematosus and polymyositis) associated with diffuse intra-alveolar hemorrhage which was proven by the transbronchial lung biopsy and hemosiderin laden macrophages in the bronchoalveolar lavage fluid. The patient is a 15-year-old school girl who has suffered from rheumatoid arthritis for 3 years and developed dyspnea 3 weeks before admission. She has a typical malar rash, oropharyngeal ulceration, mild proximal muscle weakness and tendemess with elevation of muscle enzymes. She also has crackes on both lower lung fields with increased interstitial marking on chest X-ray. Pulmonary function test revelaled severe restrictive defect with low DLCO. Transbronchial biopsy showed severe intra-alveolar hemorrhage with mild interstitial changes. Many hemosiderin-laden macrophages were found at the bronchoalveolar lavage fluid.

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