Acute Massive Pulmonary Embolism Improved by rt-PA Thrombolytic Therapy -Two Cases of Report-

Nam, Gui Hyun; Choi, Dong Chull; Chung, Hee Soon; Kim, Young Whan; Han, Sung Koo; Shim, Young Soo; Kim, Keun Youl; Han, Yong Choi

doi:1990.37.4.419

Tuberc Respir Dis > Volume 37(4); 1990 > Article

Case report

Tuberculosis and Respiratory Diseases 1990;37(4):419-427.
DOI: https://doi.org/10.4046/trd.1990.37.4.419 Published online December 1, 1990.

Acute Massive Pulmonary Embolism Improved by rt-PA Thrombolytic Therapy -Two Cases of Report-

Gui Hyun Nam, Dong Chull Choi, Hee Soon Chung, Young Whan Kim, Sung Koo Han, Young Soo Shim, Keun Youl Kim, Yong Choi Han

Department of Internal Medicine and Tuberculosis Research Institute, College of Medicine, Seoul National University, Seoul, Korea

중증 폐색전증 환자에서의 rt-PA 치험 2예

남귀현, 최동철, 정희순, 김영환, 한성구, 심영수, 김건열, 한용철

Abstract

Acute massive pulmonary embolism is a serious disease with high mortality rate if proper management is delayed. Thrombolytic therapy is indicated to coπect the hemodynamic derangement Urokinase and streptokinase are conventional drugs for this purpose, but their nonspecific systemic fibrinolytic activation can cause serious bleeding. Recombinant tissue type Plasminogen Activator (rt-PA) activates fibrin-bound plasminogen selectively, and is advocated as a local thrombolytic activator without systemic side effect. But there is little clinical experience on the usage of rt-PA in acute massive pulmonary embolism. We report two cases of acute massive pulmonary embolism improved obviously after rt-PA thrombolytic therapy together with review of literatures.