Tuberc Respir Dis > Accepted Articles
COPD
DOI: https://doi.org/10.4046/trd.2021.0015    [Accepted]
Published online May 13, 2021.
Correlation between Telomere Length and COPD-related Phenotypes: results from the chronic obstructive pulmonary disease in dusty areas (CODA) cohort
Da Hye Moon1, Jeeyoung Kim2, Myoung-nam Lim3, So Hyen Bak4, Woo Jin Kim1,2
1Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea
2Department of Internal Medicine and Environmental Health Center, Kangwon National University School of Medicine, Chuncheon, Republic of Korea
3Biomedical Research Institute, Kangwon National University, Chuncheon, Republic of Korea
4Department of Radiology, Kangwon National University Hospital, Kangwon National University of School of Medicine, Chuncheon, Republic of Korea
Correspondence:  Woo Jin Kim, Tel: 82-33-258-9364, Fax: 82-33-255-6567, 
Email: pulmo2@kangwon.ac.kr
Received: 24 January 2021   • Revised: 10 April 2021   • Accepted: 12 May 2021
Abstract
Background
COPD is a common chronic respiratory disease with increased prevalence as older. Telomeres are repetitive DNA sequences found at the end of the chromosome, which progressively shorten as cells divide. Telomere length is known to be a molecular marker of aging. This study aimed to assess the relationship between telomere length and the risk of COPD, lung function, respiratory symptoms, and emphysema index in chronic obstructive pulmonary disease in dusty areas (CODA) cohort.
Methods
We extracted DNA from the peripheral blood samples of 446 participants, including 285 COPD patients and 161 control participants. We measured absolute telomere length using quantitative real-time polymerase chain reaction. All participants underwent spirometry and quantitative computed tomography scan. Questionnaires assessing respiratory symptoms and the COPD Assessment Test (CAT)) was conducted for all participants.
Results
The mean age of participants at the baseline visit was 72.5±7.1 years. Males accounted for 72%(321 participants) of the all participants. The mean telomere length was shorter in the COPD group compared to the non COPD group (COPD; 16.81±13.90, Non-COPD; 21.97±14.43 kb). In COPD patients, 112(75.7%) were distributed as tertile1(shortest), 91 (61.1%) as tertile2 and 82 (55%) as tertile3(longest). We did not find significant associations between telomere length and lung function, exacerbation, airway wall thickness and emphysema index after adjusting for sex, age, and smoking status.
Conclusion
In this study, the relationship between various COPD phenotypes and telomere length was analyzed, but no significant statistical associations were shown.
Key Words: Telomere length, Chronic obstructive pulmonary disease, phenotype


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