| EXPERIMENTAL RE-EVALUATION STUDIES ON ISONICOTINIC ACID HYDRAZIDE lN VITRO AND IN VIVO
Ⅳ. Experimental Studies on Comparisons of Therapeutic Effects by Administration Modes of Isonicotinic Acid Hydrazide (lNH) in Mice Infected with the H37Rv Strain. |
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Sung Chin Kim1, Yong Hyun Kim2, Woo Keun Yun3 |
1Central Tuberculosis Laboratory, Korean National Tuberculosis Association
2Department of Clinical Pathology, Soo-Do Medical College
3Ehwa Woman Medical College |
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| Abstract |
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In this experiment the writers studied various modes of INH oral administration to the SM-strain mice infected with the H37Rv strain. The results were as follows 1. When doses of INH less than 1.8mg per kg were administered orally to experimental tuberculosis mice, daily twice administration of INH was less effective than daily once administration of the same amount of INH in the antibacterial efficacy and also in development of INH-resistant tubercle bacilli 2. When doses of INH larger than 18mg per kg were administered orally to experimental tuberculosis mice, there was no difference in anti-bacterial effects of INH between daily twice and daily once administration of the same amount of INH, In the mice treated twice daily with INH resistant tubercle bacilli developed more frequently. 3. Intermittant every other day administration of high doses of INH (18mg per kg and 72 mg per kg) were less effective and induced more frequently INH-resistant tubercle bacilli than daily once administration of the same amount of INH in experimental tuberculosis mice. Intermittent impact doses of INH(72mg per kg) were toxic to mice as well as daily once administration of the same doses of INH. 4. The frequency and grade of development of INH-resistent tubercle bacilli in vivo depended on the amount of administration doses, the length of time in contact with the drug and the grades of multiplication of tubercle bacili. 5. Impact therapy with the maximum administrable dose of INH(72mg per kg) is not to be recommended in tuberculosis. 6. We suggest further studies on the modes of administration and suitable effective doses of INH for man. |
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