Tuberc Respir Dis > Epub ahead of print
DOI:    [Epub ahead of print]
Published online May 16, 2023.
Problems in the Pathologic Diagnosis of Suspected Lung Cancer
Soo Han Kim, M.D, Ph.D.1,2  , Mi-Hyun Kim, M.D, Ph.D.1, Min Ki Lee, M.D, Ph.D.1, Jung Seop Eom, M.D, Ph.D.1,2 
1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea
2Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea
Correspondence:  Jung Seop Eom, Tel: 82-51-240-7889, Fax: 82-51-254-3127, 
Received: 24 October 2022   • Revised: 20 April 2023   • Accepted: 12 May 2023
Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important. This review examines the problems in the pathological diagnosis of suspected lung cancer. For successful pathological diagnosis of lung cancer, clinicians should determine the appropriate modality of the diagnostic procedure, considering individual patient characteristics, CT findings, and the possibility of complications. Furthermore, clinicians should make efforts to obtain a sufficient amount of tissue sample using non- or less-invasive procedures for pathological diagnosis and biomarker analysis.
Key Words: Lung Cancer, Diagnosis, Problem

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