| Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors |
Jong Hwan Jeong1 
, Manbong Heo1
, Sunghoon Park2, Su Hwan Lee3, Onyu Park4, Taehwa Kim5,6, Hye Ju Yeo5,6, Jin Ho Jang5,6, Woo Hyun Cho5,6, Jung-Wan Yoo1
, on behalf of the Korean Intensive Care Study Group |
1Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea
2Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
3Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
4BioMedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
5Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Internal Medicine, Transplant Research Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
6Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea |
Correspondence:
Jung-Wan Yoo, Tel: 82-55-750-9763,
Email: chareok@gmail.com
|
Received: 17 October 2024 • Revised: 19 November 2024 • Accepted: 27 November 2024
*Jong Hwan Jeong and Manbong Heo contributed equally to this study as co-first authors. |
| Abstract |
Background
The development of frailty at hospital discharge affects the clinical outcomes in severe coronavirus disease 2019 (COVID-19) survivors who had no frailty before hospitalization. We aimed to describe the prevalence of new frailty using the clinical frailty scale (CFS) and evaluate its associated factors in patients with severe COVID-19 without pre-existing frailty before hospitalization.
Methods
We performed a secondary analysis of clinical data from a nationwide retrospective cohort collected from 22 hospitals between January 1, 2020 and August 31, 2021. The patients were at least 19 years old and survived until discharge after admission to the intensive care unit (ICU) because of severe COVID-19. Development of new frailty was defined as a CFS score ≥5 at hospital discharge.
Results
Among 669 severe COVID-19 survivors without pre-existing frailty admitted to the ICU, the mean age was 65.2±12.8 years, 62.5% were male, and 50.2% received mechanical ventilation (MV). The mean CFS score at admission was 2.4±0.9, and new frailty developed in 27.8% (186/483). In multivariate analysis, older age, cardiovascular disease, CFS score of 3–4 before hospitalization, increased C-reactive protein level, longer duration of corticosteroid treatment, and use of MV and extracorporeal membrane oxygenation were identified as factors associated with new-onset frailty.
Conclusion
Our study suggests that new frailty is not uncommon and is associated with diverse factors in survivors of severe COVID-19 without pre-existing frailty. |
| Key Words:
Severe COVID-19, Frailty, Clinical Frailty Scale, Intensive Care Unit |
|
PDF Links
Data Sharing Statement
Full text via DOI
Download Citation
