Tuberc Respir Dis > Volume 72(2); 2012 > Article
Tuberculosis and Respiratory Diseases 2012;72(2):197-202.
DOI: https://doi.org/10.4046/trd.2012.72.2.197    Published online February 1, 2012.
A Case of Microscopic Polyangiitis Presented as Pleural Effusion.
Jin Kyeong Shin, Soon Seog Kwon, Ki Hoon Park, Hee Joung Lee, Yong Hyun Kim
1Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea. kyh30med@catholic.ac.kr
2Department of Pathology, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea.
Abstract
Microscopic polyangiitis is a necrotizing vasculitis, characterized by inflammation of small vessels (capillaries, venules, and arterioles) with few or no immune deposits. The kidneys are the most commonly affected organs and are involved in 90% of patients, whereas pulmonary involvement occurs in a minority of cases (10% to 30%). In cases of lung disease, diffuse alveolar hemorrhage with pulmonary capillaritis is the most common manifestation. Microscopic polyangiitis is strongly associated with antineutrophil cytoplasmic autoantibody, which is a useful diagnostic serological marker. We report a case of microscopic polyangiitis presented as pleural effusion in a 67-year-old female. Pleural effusions have been reported in some cases previously, but the number of cases were small and their characteristics have not been well described. This report describes characteristic findings of pleural fluid and its histological features in a case of microscopic polyangiitis.
Key Words: Microscopic Polyangiitis, Pleural Effusion, Antibodies, Antineutrophil Cytoplasmic


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