Overexpression of Periostin Protein in Non-Small Cell Lung Carcinoma is Not Related with Clinical Prognostic Significance.

Park, Won Young; Shin, Dong Hoon; Kim, Jae Ho; Lee, Min Ki; Lee, Ho Seok; Lee, Chang Hun

doi:2012.72.2.132

Tuberc Respir Dis > Volume 72(2); 2012 > Article

Original Article

Tuberculosis and Respiratory Diseases 2012;72(2):132-139.
DOI: https://doi.org/10.4046/trd.2012.72.2.132 Published online February 1, 2012.

Overexpression of Periostin Protein in Non-Small Cell Lung Carcinoma is Not Related with Clinical Prognostic Significance.

Won Young Park, Dong Hoon Shin, Jae Ho Kim, Min Ki Lee, Ho Seok Lee, Chang Hun Lee

¹Department of Pathology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. cnlee@pusan.ac.kr
²Department of Physiology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
³Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. leemk@pusan.ac.kr
⁴Department of Thoracic Surgery, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
⁵Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Abstract

BACKGROUND
Periostin is preferentially expressed in periosteum, indicating a potential role in bone formation. Recently, there have been emerging controversies about its role in invasion and metastasis of human malignancies. We attempted to determine the clinicopathological significance of periostin expression in non-small cell lung carcinoma (NSCLC). METHODS: Immunohistochemical staining of periostin protein from 91 cases of NSCLCs was performed using tissue microarray blocks. The results were correlated with clinicopathological parameters. RESULTS: Positive reaction to periostin was predominantly noted in the tumor stroma. The strongest reaction presented as a band-like pattern just around the tumor nests. Non-neoplastic lung tissue and most in-situ carcinomas did not show a positive reaction in their stroma. With respect to tumor differentiation, moderate to poor differentiated tumors (47/77) revealed even higher periostin expression than the well-differentiated ones (4/14) (p=0.024). High periostin expression was positively correlated with E-cadherin and p53 expression, but was not related with patient age, sex, tumor type, PCNA index, b-catenin, cyclin D1, pTNM-T, pTNM-N, stage, and patient survival (p>0.05). CONCLUSION: These results suggest that periostin might play a role during the biological progression of NSCLC, but may not be related to the clinical prognostic parameters.

Key Words: Carcinoma, Non-Small-Cell Lung, Cadherins, Genes, p53