First Isolation of Segniliparus rugosus from a Patient with Radiologic Features Similar to Non-Tuberculous Mycobacteriosis.

Choi, Sun Mi; Kang, Hyo Jae; Jeong, Yun Jeong; Lim, Joo Hyun; Choe, Won Seok; Hwang, Sang Hyun; Park, Jinkyeong; Hwangbo, Bin; Lee, Hee Seok

doi:2012.72.1.82

Tuberc Respir Dis > Volume 72(1); 2012 > Article

Case Report

Tuberculosis and Respiratory Diseases 2012;72(1):82-87.
DOI: https://doi.org/10.4046/trd.2012.72.1.82 Published online January 1, 2012.

First Isolation of Segniliparus rugosus from a Patient with Radiologic Features Similar to Non-Tuberculous Mycobacteriosis.

Sun Mi Choi, Hyo Jae Kang, Yun Jeong Jeong, Joo Hyun Lim, Won Seok Choe, Sang Hyun Hwang, Jinkyeong Park, Bin Hwangbo, Hee Seok Lee

¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
²Department of Laboratory Medicine, National Cancer Center, Goyang, Korea.
³Center for Lung Cancer, National Cancer Center, Goyang, Korea. jekyde@yahoo.co.kr

Abstract

In 2005, a group of mycolic acid-containing bacteria was characterized as belonging to a novel genus, Segniliparus with species Segniliparus rugosus and S. rotundus. We report a case of the S. rugosus isolated from a 54-year-old woman with radiologic features mimicking that of non-tuberculous mycobacteriosis (NTM). When the patient first visited our hospital, an acid-fast bacteria (AFB) smear tested positive and Mycobacterium tuberculosis polymerase chain reaction (TB PCR) was negative in the bronchoalveolar lavage sample. After 2 months, the growing colonies were reported as NTM, but could not be identified because they had died. One year after the initial visit, induced sputum samples showed the same results, positive AFB smear and negative TB PCR. At this point, the growing colonies were identified as S. rugosus. Therefore, we should consider Segniliparus genus as a differential diagnosis for AFB in respiratory specimens in addition to the genus Mycobacterium.

Key Words: Actinomycetales