E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients.

Cho, Jung Nam; Yoon, So Yeon; Hyun, Dae Sung

doi:2011.71.5.349

Tuberc Respir Dis > Volume 71(5); 2011 > Article

Original Article

Tuberculosis and Respiratory Diseases 2011;71(5):349-354.
DOI: https://doi.org/10.4046/trd.2011.71.5.349 Published online November 1, 2011.

E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients.

Jung Nam Cho, So Yeon Yoon, Dae Sung Hyun

Department of Internal Medicine, The Catholic University of Daegu School of Medicine, Daegu, Korea. hdsomn@cu.ac.kr

Abstract

BACKGROUND
Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC. METHODS: Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008. RESULTS: The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients. CONCLUSION: The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.

Key Words: Lung Neoplasms, oncogene protein E6, human papillomavirus type 18