| Lack of Association between the Klotho Gene and COPD. |
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Woo Jin Kim, Yeon Mok Oh, Tae Hyung Kim, Ji Hyun Lee, Eun Kyung Kim, Jin Hwa Lee, Sang Min Lee, Tae Rim Shin, Ho Il Yoon, Seong Yong Lim, Sang Do Lee |
1Department of Internal Medicine, Kangwon National University, Chuncheon, Korea.
2Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sdlee@amc.seoul.kr
3Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
5Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
7Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hanllym University College of Medicine, Seoul, Korea.
8Respiratory Center, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine, Seongnam, Korea.
9Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. symd21.lim@samsung.com |
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| Abstract |
BACKGROUND
Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity. METHODS: A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear regression was performed to investigate their association with emphysema severity in COPD subjects. RESULTS: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity. CONCLUSION: Genetic polymorphisms of the klotho gene were not associated with COPD in a Korean population. |
| Key Words:
Pulmonary Disease, Chronic Obstructive, Polymorphism, Genetic |
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