Tuberc Respir Dis > Volume 70(3); 2011 > Article
Tuberculosis and Respiratory Diseases 2011;70(3):257-260.
DOI:    Published online March 1, 2011.
A Case of Pulmonary Fibrosis with Microscopic Polyangiitis.
Jae Ho Jeong, Sung Hee Kang, Se Jung Park, Dal Yong Kim, Woo Sung Kim, Dong Soon Kim, Jin Woo Song
1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Department of Diagnostic Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
A 65-year-old woman was admitted due to poor oral intake and a dry cough over the previous 3 months. The physical examination was remarkable for bibasilar crackles, and plain chest radiography showed reticulation in both lower lung fields. A pulmonary function test demonstrated a restrictive pattern with a reduced diffusing capacity of the lung for carbon monoxide. High resolution computed tomography showed reticulation and honey-combing in both peripheral lung zones, which was consistent with usual interstitial pneumonia pattern. Her skin showed livedo reticularis. The erythrocyte sedimentation rate and C-reactive protein level were elevated, and hematuria was noted on urinary analysis. A serologic test for auto-antibodies showed seropositivity for Myeloperoxidase-Anti-neutrophil cytoplasmic antibody (MPO-ANCA). A kidney biopsy was performed and showed focal segmental glomerulosclerosis. She was diagnosed as having pulmonary fibrosis with microscopic polyangiitis (MPA) and treated with high dose steroids. Here we report a case of pulmonary fibrosis coexistent with microscopic polyangiitis.
Key Words: Pulmonary Fibrosis, Microscopic Polyangiitis, Antibodies, Antineutrophil Cytoplasmic

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