A Case of Middle Mediastinal Malignant Paraganglioma. |
Sung Bum Park, Silvia Park, Sun Ha Bang, Eun Kyung Kim, Kyeongman Jeon, Won Jung Koh, Gee Young Suh, Man Pyo Chung, Hojoong Kim, O Jung Kwon, Young Hyeh Go, Sang Won Um |
1Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea. 2Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sangwonum@skku.edu |
|
Abstract |
Pheochromocytomas are neuroendocrine tumors of chromaffin cell that originate in the paraganglia of the adrenal medulla. Approximately 10% of pheochromocytomas are found in the extra-adrenal paraganglia and are called paragangliomas. However, cases of middle mediastinal paragangliomas are very rare. In this case, the patient presented with a voice change and a headache. A middle mediastinal soft tissue mass with marked enhancement was detected on computed tomography of the chest. The 24-hour urine catecholamine level was markedly elevated. The middle mediastinal mass was biopsied via mediastinoscopy and the resulting immunohistochemical staining was compatible with a diagnosis of middle mediastinal paraganglioma. The mass was resected surgically and the symptoms were relieved. |
Key Words:
Paraganglioma, Mediastinum, Neoplasms |
|