A Case of Cranial Nerve Palsy as a Paraneoplastic Syndrome in Non-Small Cell Lung Cancer.

Lee, Young Mi; Sim, Woo Ho; Yoon, Sun Och; Kim, Song Yee; Park, Jung Soo; Kho, Bo Gun; Byun, Min Kwang; Choi, Young Chul; Kim, Hyung Jung

doi:2011.70.2.160

Tuberc Respir Dis > Volume 70(2); 2011 > Article

Case Report

Tuberculosis and Respiratory Diseases 2011;70(2):160-164.
DOI: https://doi.org/10.4046/trd.2011.70.2.160 Published online February 1, 2011.

A Case of Cranial Nerve Palsy as a Paraneoplastic Syndrome in Non-Small Cell Lung Cancer.

Young Mi Lee, Woo Ho Sim, Sun Och Yoon, Song Yee Kim, Jung Soo Park, Bo Gun Kho, Min Kwang Byun, Young Chul Choi, Hyung Jung Kim

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. khj57@yuhs.ac
²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
³Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Paraneoplastic neurologic syndrome is a group of assorted disorders resulting from damage to the nervous system in cancer, remote from primary site, and not related to metastasis, infection, or metabolic disorder associated with cancer. Patient with small cell lung cancer sometimes shows various neurological syndromes, but patient with non-small cell lung cancer rarely shows neurologic syndromes and few antineuronal antibodies have been found. Here, we report a case of 53-year-old male patient who developed ptosis and extraocular muscular limitation of left eye due to third and forth cranial nerve palsy in non-small cell lung cancer without brain metastasis. These neurologic symptoms improved after lobectomy without any other treatment immunotherapy.

Key Words: Paraneoplastic Syndromes, Nervous System, Carcinoma, Non-Small-Cell Lung, Paralysis, Cranial Nerves