Tuberc Respir Dis > Volume 69(5); 2010 > Article
Tuberculosis and Respiratory Diseases 2010;69(5):368-374.
DOI:    Published online November 1, 2010.
Relation between Subjective Symptoms and Rhinolaryngoscopic Findings or Sputum Eosinophilia in Chronic Cough Patients.
Hyun Kuk Kim, Eun Young Choi, Jae Seung Lee, Yun Jeong Bae, Jin Woo Song, Tae Bum Kim, You Sook Cho, Hee Bom Moon, Sang Do Lee, Yeon Mok Oh
1Department of Pulmonary and Critical Care Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
2Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
3Department of Allergy, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
4Asthma Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Rhinolaryngoscopy and sputum examination are popular tests for the evaluation of chronic cough. Little is known about the relationship between symptoms and rhinolaryngoscopic findings or sputum eosinophilia in chronic cough patients. METHODS: One hundred patients, who had chronic cough with normal chest radiography and who also had undergone both rhinolaryngoscopy and induced sputum analysis, were reviewed retrospectively. Eleven associated symptoms of chronic cough were asked; postnasal drip (PND) and laryngopharyngeal reflux (LPR) were examined by rhinolaryngoscopy. Induced sputum analysis was performed for evaluation of sputum eosinophilia. Cross tabulation analyses with chi-square tests were used to evaluate the relationship between symptoms and objective findings. RESULTS: The most frequent symptom was sputum (70%). The prevalence of PND and LPR on rhinolaryngoscopy were 56% (56/100) and 25.6% (22/86), respectively. Sputum eosinophilia was observed in 23 (23.7%) of 97 patients. The dyspnea (p=0.001), sputum (p=0.003), nasal obstruction (p=0.023), and postnasal drip sense (p=0.025) were related with PND on rhinolaryngoscopy. LPR on rhinolaryngoscopy was not related with any symptoms. Dyspnea (p=0.003), wheezing (p=0.005), nasal obstruction (p=0.013), and belching (p=0.018) were related with sputum eosinophilia. CONCLUSION: Any symptoms might not be related with LPR on laryngoscopy. Some symptoms might be related with PND on rhinoscopy or with sputum eosinophilia.
Key Words: Cough, Chronic Disease, Rhinoscopy, Laryngoscopy, Sputum, Eosinophils
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