A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion. |
Hyun Kyung Kim, Su Woo Kim, Hye Won Kang, Kyoung Joo Kwon, Hye Sung Park, Yon Ju Ryu, Jin Hwa Lee, Eun Mi Chun, Young Joo Cho, Jung Hyun Chang |
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. hs1017@ewha.ac.kr |
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Abstract |
Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature. |
Key Words:
Hypersensitivity, Delayed, Anaphylaxis, Purpura, Paclitaxel |
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