Tuberc Respir Dis > Volume 68(3); 2010 > Article
Tuberculosis and Respiratory Diseases 2010;68(3):146-154.
DOI:    Published online March 1, 2010.
The Recent Status of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea.
Sun Young Kim, Hee Jin Kim, Chang Ki Kim, Hye Ryung Yoon, Hye Gyung Bae, Sun Hwa Lee, Nackmoon Sung, Dae Yeon Kim, Gang Young Lee, Young Soo Cho, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Tae Sun Shim
1Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Korean Institute of Tuberculosis, Seoul, Korea.
3Seoul Medical Science Institute, Seoul, Korea.
4Green Cross Reference Laboratory, Seoul, Korea.
5Neodin Medical Institute, Seoul, Korea.
6National Masan Hospital, Masan, Korea.
7National Mokpo Hospital, Mokpo, Korea.
8Seobuk Hospital, Seoul, Korea.
The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has become a serious worldwide problem. However, there is insufficient data regarding the current status of MDR-TB and XDR-TB in Korea. This study examined the recent status of MDR- and XDR-TB using the data from 7 laboratories, in which almost all drug susceptibility tests (DST) for Mycobacterium tuberculosis were performed. METHODS: The patients' identification data and DST results were collected from all 7 laboratories from 2001 to 2006 and the number of patients with MDR-TB and XDR-TB were calculated. RESULTS: The number of DSTs was 140,638 for 6 years with an increasing incidence each year (p<0.001). The number of DST with MDR results was 18,510 and personal identifying information was obtained in 16,640 (89.9%) tests. The number of MDR-TB patients from 2001 to 2006 was 2,329, 2,496, 2,374, 2,300, 2,354, and 2,178, respectively, when counting the duplications in a year as one patient. The number of MDR-TB patients when counting the duplications in 6 years as one patient was 2,281, 1,977, 1,620, 1,446, 1,512, and 1,373, respectively. When the same method was adopted, the number of XDR-TB patients was 191, 238, 282, 260, 272, and 264, respectively, and 189, 150, 130, 90, 122, and 110 patients, respectively. CONCLUSION: Despite the national efforts to control TB, there are still a large number of MDR- and XDR-TB patients in Korea.
Key Words: Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Microbial Sensitivity Tests, Korea

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