A Case of Sarcoidosis with Pancytopenia as Resulting from Bone Marrow Involvement.

Park, Tai Sun; Kim, Dae Young; Park, Seo Jin; Kim, Yi Rang; Na, Soo Young; Park, Jin Wook; Oh, Dong Wook; Choi, Jun Seok; Jo, Jung Min; Chang, Youjin; Kim, Won Young; Choi, Chang Min

doi:2009.67.6.560

Tuberc Respir Dis > Volume 67(6); 2009 > Article

Case Report

Tuberculosis and Respiratory Diseases 2009;67(6):560-564.
DOI: https://doi.org/10.4046/trd.2009.67.6.560 Published online December 1, 2009.

A Case of Sarcoidosis with Pancytopenia as Resulting from Bone Marrow Involvement.

Tai Sun Park, Dae Young Kim, Seo Jin Park, Yi Rang Kim, Soo Young Na, Jin Wook Park, Dong Wook Oh, Jun Seok Choi, Jung Min Jo, Youjin Chang, Won Young Kim, Chang Min Choi

¹Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ccm@amc.seoul.kr
²Department of Hematology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
³Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Abstract

Sarcoidosis is a granulomatous disease that can involve any organ, although it primarily involves the lungs, intrathoracic lymph nodes, skin, and eyes. We present a case of sarcoidosis with pancytopenia, resulting from bone marrow involvement. A 35-year-old man was admitted to hospital for chronic cough and blurred vision. On chest computed tomography, there were multiple pulmonary nodules and mediastinal lymph nodes enlargement. As the patient also showed pancytopenia, we performed a bone marrow biopsy, as well as a transbronchial lung biopsy. Both biopsies showed non-caseating granulomas. We diagnosed the patient with sarcoidosis with pulmonary, bone marrow, uvea, liver and spleen involvement. After oral steroid therapy, the patient's symptoms as well as his pancytopenia improved. We present this case to demonstrate the significance of bone marrow biopsy in cases of sarcoidosis with pancytopenia, as well the possibility of clinical improvement with steroid treatment.

Key Words: Sarcoidosis, Pancytopenia, Bone Marrow