Tuberc Respir Dis > Volume 67(1); 2009 > Article
Tuberculosis and Respiratory Diseases 2009;67(1):8-13.
DOI:    Published online July 1, 2009.
Association of Insulin Receptor Substrate-1 G972R Variant with Non-small Cell Lung Cancer Risk.
Chang Youl Lee, Chul Min Ahn, Jeong Hee Jeon, Hyung Jung Kim, Se Kyu Kim, Joon Chang, Sung Kyu Kim, Yoon Soo Chang
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
3Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
4Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea.
The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3'-kinase (PI3K) pathway. IRS-1 activation of the (PI3K) pathway regulates IGF-mediated survival, enhancement of cellular motility and apoptosis. Therefore, we attempted to ascertain whether IRS-1 genetic variations affect an individual's risk for non-small cell lung cancer (NSCLC). METHODS: Two-hundred and eighteen subjects, either diagnosed with NSCLC or control subjects, were matched by age, gender and smoking status. Genomic DNA from each subject was amplified by PCR and analyzed according to the restriction fragment length polymorphism (RFLP) profile to detect the IRS-1 G972R polymorphism. RESULTS: The frequencies of each polymorphic variation, in the control population, were as follows: GG=103 (94.5%) and GR=6 (5.5%); for the NSCLC subjects, the genotypic frequencies were as follows: GG=106 (97.2%) and GR=3 (2.8%). We could not demonstrate statistically significant differences in the genotypic distribution between the NSCLC and the control subjects (p=0.499, Fisher's Exact test). The relative risk of NSCLC, associated with the IRS-1 G972R polymorphic variation, was 1.028 (95% CI; 0.63~9.90). In addition, we found no differences between polymorphic variants with regard to the histological subtype of NSCLC. CONCLUSION: We did not observe any noteworthy differences in the frequency of the IRS-1 G972R polymorphism in NSCLC patients, compared to control subjects. These results suggest suggesting that, in our study population, the IRS-1 G972R polymorphism does may not appear to be associated with an increased risk of NSCLC.
Key Words: Insulin receptor substrate-1, Insulin-like growth factor, Non-small cell lung cancer

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