Tuberc Respir Dis > Volume 66(4); 2009 > Article
Tuberculosis and Respiratory Diseases 2009;66(4):324-328.
DOI:    Published online April 1, 2009.
A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Chemotherapy in a Patient with Non-Small-Cell Lung Cancer.
Kyoung Ju Lee, Jae Young Moon, Sung Yong Lee, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jung Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.
Key Words: Inappropriate ADH syndrome, Non-small-cell lung carcinoma, Hyponatremia, Carboplatin

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