Tuberc Respir Dis > Volume 66(1); 2009 > Article
Tuberculosis and Respiratory Diseases 2009;66(1):20-26.
DOI:    Published online January 1, 2009.
Association between Bone Marrow Hypermetabolism on (18)F-Fluorodeoxyglucose Positron Emission Tomography and Response to Chemotherapy in Non-Small Cell Lung Cancer.
Hee Yun Seol, Jeong Ha Mok, Seong Hoon Yoon, Ji Eun Kim, Ki Uk Kim, Hye Kyung Park, Seong Jang Kim, Yun Seong Kim, Min Ki Kim, Soon Kew Park
1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
2Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
(18)F-Fluorodeoxyglucose positron emission tomography (FDG-PET) is widely used for the diagnosis and staging of non-small cell lung cancer (NSCLC). The aim of this study is to determine whether the bone marrow hypermetabolism seen on FDG-PET predicts a response to chemotherapy in patients with NSCLC. METHODS: We evaluated the patients with advanced NSCLC and who were treated with combination chemotherapy. For determination of the standardized uptake value (SUV) of the bone marrow (BM SUV) on FDG-PET, regions of interest (ROIs) were manually drawn over the lumbar vertebrae (L1, 2, 3). ROIs were also drawn on a homogenous transaxial slice of the liver to obtain the bone marrow/ liver SUV ratio (BM/L SUV ratio). The response to chemotherapy was evaluated according to the Response Evaluation Criteria in Solid Tumor (RECIST) criteria after three cycles of chemotherapy. RESULTS: Fifty-nine NSCLC patients were included in the study. Multivariate analysis was performed using a logistic regression model. The BM SUV and the BM/L SUV ratio on FDG-PET were not associated with a response to chemotherapy in NSCLC patients (p=0.142 and 0.978, respectively). CONCLUSION: The bone marrow hypermetabolism seen on FDG-PET can not predict a response to chemotherapy in NSCLC patients.
Key Words: Non-small cell lung cancer, Bone marrow, (18)F-Fluorodeoxyglucose positron emission tomography, Chemotherapy

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