Tuberc Respir Dis > Volume 65(4); 2008 > Article
Tuberculosis and Respiratory Diseases 2008;65(4):301-307.
DOI: https://doi.org/10.4046/trd.2008.65.4.301    Published online October 1, 2008.
Prognostic Utility of the Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Patients with Acute Respiratory Distress Syndrome.
Jin Won Huh, Hoon Jung, Chae Man Lim, Younsuck Koh, Sang Bum Hong
1Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
2Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sbhong@amc.seoul.kr
Abstract
BACKGROUND
The triggering receptor expressed on myeloid cells-1 (TREM-1) is an activating receptor that is expressed on the surface of neutrophils and mature monocytes when stimulated with several microbial components, which can amplify the inflammatory response. This study analyzed the prognostic value of the sTREM-1 levels in patients with acute respiratory distress syndrome (ARDS). METHODS: The bronchoalveolar lavage (BAL) fluid and blood was collected prospectively from 32 patients with ARDS, 15 survivors and 17 nonsurvivors. An enzyme-linked immunosorbent assay was performed to measure the sTREM-1. The following data was obtained: APACHE II score, Clinical Pulmonary Infection Score (CPIS), BAL fluid analysis, C-reative protein. Mortality in the ICU was defined as the end point. RESULTS: The serum sTREM-1 level was significantly higher in the nonsurvivors than survivors (54.3+/-10.3 pg/ml vs. 22.7+/-2.3 pg/ml, p<0.05). The sTREM-1 level in the serum, but not in the BAL fluid, was an independent predictor of the ICU mortality (OR: 22.051, 95% CI: 1.780~273.148, p<0.016), and a cut-off value of > or =33 pg/ml yielded a diagnostic sensitivity of 71% and specificity of 93%. CONCLUSION: The serum sTREM-1 level may be a useful predictor of the outcome of ARDS patients.
Key Words: Acute respiratory distress syndrome, Triggering receptor expressed on myeloid cells-1, Prognosis, Mortality


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