A Case of Central Diabetes Insipidus in Patient with Non-small Cell Lung Cancer.

Hwang, Eun Mi; Oh, You Kyoung; Kim, Ki Jo; Kim, Yong Hyun; Yoon, Hyoung Kyu; Song, Jeong Sup

doi:2004.57.3.284

Tuberc Respir Dis > Volume 57(3); 2004 > Article

Original Article

Tuberculosis and Respiratory Diseases 2004;57(3):284-288.
DOI: https://doi.org/10.4046/trd.2004.57.3.284 Published online September 1, 2004.

A Case of Central Diabetes Insipidus in Patient with Non-small Cell Lung Cancer.

Eun Mi Hwang, You Kyoung Oh, Ki Jo Kim, Yong Hyun Kim, Hyoung Kyu Yoon, Jeong Sup Song

Division of Pulmonology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea. jssong@catholic.ac.kr

Abstract

Central diabetes insipidus (DI) is a disease caused by insufficient release of antidiuretic hormone. Central DI with lung cancer is very rare. Most of them are caused by the pituitary metastasis, and rarely, by the paraneoplastic syndromes. Central DI is diagnosed by the water deprivation test. The treatment consists of surgical resection, radiotherapy and administration of desmopressin. We report an unusual case of central DI with non-small cell lung cancer. The diagnosis was confirmed by water deprivation test. After the administration of desmopressin, the urine osmolarity was increased. The patient's symptoms and urine osmolarity were improved by intranasal desmopressin.

Key Words: Non-small cell lung cancer, Central diabetes insipidus