| Clinical Effects of the Capreomycin on Pulmonary Tuberculosis |
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Joong K. Oh, Sang Baik Oh, Joo Kyung Lee, Il Taik Lim, Jung Hee Lee, Jai Won Kim, Hae Young Chung |
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Department of Chest Medicine, The National Medical Center, Seoul, Korea |
| 폐결핵에 대한 Capreomycin의 임상적 효과 |
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오중근, 오상백, 이주경, 임일택, 이정희, 김재원, 정혜영 |
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| Abstract |
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A: Patients. having been on primary triple therapy under the diagnosis of pulmonary tuberculosis.
were chosen for the subjects among the ambulatory cases at the Department of Chest Medicine.
National Medical Center.
B: The subjects were divided into 2 groups and put on the scheduled one year anti-tbc medication during the period of March 1968 to March 1969.
The therapeutic regimens were as follows:
Group I : 1) PAS-f- INH-f- SM (2.0-3.0 gm / W) for the first 6 months period 2) PAS-f- INH-f-CAPREOMYCIN (2.0-3.0 gm/ W) for the second 6 months period Group ll: 1) PAS-f- INH-f- SM (2.0-3.0 gm / W) for the 12 months of the full course of the project
C: Chest X- ray views were studied at every 2 to 3 months period throughout the full course of the
project as of the improvement of the pulmonary lesions. ie: infiltrations and cavitary lesions separately.
With the above study the comparison study was done between the Group I and Group II.
D: Throughout the full course of the therapy the rates of the improvement of the pulmonary infiltrations were as follows:
1) Moderately to markedly improved cases Group I : 45 % Group ll: 11 %
2) Slightly improved cases Group I : 28% Group II: 44%
E : The ratcs of the improvement of cavitaty lesions arc as follows :
1) Markedly improvcd cases Group I: 50% Group ll: 43% 2, Slightly improved cases Group I: 20% Group ll: 28%
F: The net improvement rates of the pulmonary infiltration, excluding those of the first 6 months period, that is calIed absoltue comparison are as folIows:
1) Moderately to markedly improved cases Group I : 45% Group ll: 0; 2) SIightly improved cases Group I: 50% Group II: 40%
G: The net improvement rates of the cavitary lesions, excluding those of the first 6 months period.
ie: the absolute comparison, are as foIIows:
1) Markedly improved cases Group I : 34% Group ll: 0
2) Slightly improved cases Group i: 22% Group ll: 40% |
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