Tuberc Respir Dis > Volume 58(4); 2005 > Article
Tuberculosis and Respiratory Diseases 2005;58(4):392-398.
DOI:    Published online April 1, 2005.
Clinical Observational study of Pulmonary Tuberculosis for admitted patients at a National Tuberculosis Hospital: Comparison with the previous results in 1995.
Seung Kyu Park, In Hee Lee, Byoung Ju Kim
Clinical Research Center for Tuberculosis, National Masan Tuberculosis Hospital, Masan, Korea.
The last national tuberculosis survey was carried out in 1995. In 2000, the KTBS(Korean Tuberculosis Surveillance System) replaced a previous national survey. However, the KTBS does not show some of the important epidemiological indexes such as the prevalence of positive tuberculosis or the drug resistance rate. The aim of this study was to compare the clinical features of pulmonary tuberculosis patients admitted to a national tuberculosis hospital in 1995 and 2002. From this study, the authors expect to estimate the trend of the clinical features of tuberculosis in Korea even though it can not represent the Korean tuberculosis situation as a whole. METHOD: A cross sectional analysis of the clinical features for 331 pulmonary tuberculosis in-patients admitted to the National Masan Tuberculosis Hospital as of Dec. 2002, was carried out and these results were compared with those reported in 1995. RESULTS: In comparison with the data reported in 1995, the mean age was increased by 3.6 years (44.1+/-14.6 vs 47.7+/-16.4, p<0.01). The number of past tuberculosis history and used anti-tuberculous drugs prior to admission decreased from 2.0+/-1.7 and 6.1+/-2.3 to 1.7+/-1.8 and 4.6+/-3.6(p<0.05, p<0.001), respectively. While the resistance rate for anti-tuberculous drugs was similar (81.0% vs 77.6%), the initial resistance rate(10.5% vs 21.4%) and initial MDR rate(2.4% vs 16.5%) increased significantly(p=0.012, p=0.001, respectively). In 1995, the public health communities were in charge of approximately 65% of newly diagnosed tuberculosis cases, but this reduced to 40.5% in 2002(p<0.001). CONCLUSION: The existing national TB program (NTP) needs to be revised and strengthened in order to cope with the unfavorably changing situation of the domestic TB problem because the number of TB patients has not decreased and the initial resistance rate has increased greatly. Furthermore, the public and private sectors should cooperate each other to control the TB problem effectively because the private sector is now managing more than half of the TB patients.
Key Words: Pulmonary tuberculosis, MDR-TB, Drug resistance

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