| p53 Expression Patterns in Non-small Cell Lung Cancers |
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Sun Young Kim1, Seok Cheol Hong1, Pyo Seong Han1, Jong Jin Lee1, Hai Jeong Cho1, Ae Kyoung Kim1, Ju Ock Kim1, Sang Sook Lee2 |
1Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, korea
2Department of Anatomy and Pathology, College of Medicine, Keimyung University , Daejeon, korea |
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| Abstract |
Background
p53 is currently considered as a tumor-suppressive gene product, and its alterations are suggested to be involved in several human malignancies, including non-small cell lung cancers. p53 expression rates are variable in many reports and among cell types. Also, whether the phase of p53 expression is early or late during carcinogenesis is not certain. Thus, We have investigated to evaluate p53 expression rates of the various cell types and tissues and identify expression phase (early or late).
Methods
We obtained 71 tissue from 50 non-small cell lung cancer patients and performed the simple immunohistochemical staining using nonspecific monoclonal antibody (NCL-p53D07).
Results
1) 1n non-small cell lung cancer patients. the expression rate of lungs (46.5%) is higher than that (25.0%) of lymph nodes. But, there is no significant difference between two groups.
2) Among the various cell types, p53 expression rates in squamous cell carcinoma and adenocarcinoma are 58.3% and 50.0% respectively without significant difference.
3) p53 expression rates in various stages are 33.3 %, 60.0% , 40.0% , 60.0% a nd 66.7% in stage 1 , II ,
IIIa, IIIb and 1V, respectively with no significant difference.
4) p53 expression rates in the various T parameters are 33.3% , 50.0%, 16.7% and 100% in Tl , T 2,
T3 and T4, respectively and p53 expression rates in the various N parameters are 27.3%, 22.2% and 25.0% in Nl , N2 and N3, respectively. There are no significant differences in the expression rates among varous T & N parameters.
5) p53 expression rates of lymph nodes in patients who have positive stains in lungs are 12.5% and 50.0% in Nl and N2.
6) p53 expression rates of all lymph nodes in patients who have negative stains in lungs are 0.0%.
Conclusion
The above results show that p53 expression rate in non-smalJ cell lung cancers is not correlated with cell type and progression of stage and it is thought to need further investigations about at what phase p53 expression influences the development and progression of lung cancers.
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| Key Words:
p53 protein expression rate, Non-small cell lung cancer Tumor suppressive Gene, Immunohistochemistry |
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