Clinical Investigations on the Antituberculous Effectiveness of Alpha-Ethyl-Thioisonicotinamide in Pulmonary Tuberculosis

Kang, Seun Je

doi:1960.0.9.41

Tuberc Respir Dis > Issue 9; 1960 > Article

Tuberculosis and Respiratory Diseases 1960;9:41-45.
DOI: https://doi.org/10.4046/trd.1960.9.1.41 Published online December 1, 1960.

Clinical Investigations on the Antituberculous Effectiveness of Alpha-Ethyl-Thioisonicotinamide in Pulmonary Tuberculosis

Seun Je Kang

Department of Internal Medicine, Medical College, Seoul National University, Seoul, Korea

α-ETHYL-THIOISONICOTINAMIDE (1314Th)의 항결핵성에 대한 임상 관찰

강선제

Abstract

A clinical investigation has been made of the use of Alpha ethyl-thioisonicotinamide in 20 patients with pulmonary tuberculosis. In 19 of the patients the tuberculosis was chronic and the drug was administered with other 2 antituberculous drugs for a period of 5 months or more, 1 was recent disease and the drug was administered alone. The Alpha-ethyl-thioisonicotinamide was often badly to lerated and the patients complained digestive disorders such as anorexia nausea or gastric irritation. There was no toxic evidence that the drug was toxic for the liver, kidney, or the hematopoietic system. The neurotoxicity of Alpha-ethyl-thisisoni-cotinamide(1314 Th) appeared to 3 females an 1 male and it was relieved by intramuscular injection of pyridoxine 75mg to 100mg daily. The 1314Th had ad undeniable influence on the clinical and bacteriologic evidence of the pulmonary tuberculosis in the patients treated. The bacterlologic effects were particularly evident. A lack of improvement was observed in several patients. It is believed that the 1314Th shouldn't be used alone in the initial treatment of recently developed pulmonary tuberculosis, but should be administered in association with INH SM PAS or Cycloserine. The results obtained when the 1314Th was used in multiple drug regimens including INH PAS and Cycloserine, were considered to be most satisfactory. When used in association with other drugs the 1314Th has brought considerable improvement of the lesions in patients who had received much previous therapy but whose strains of T.B. bacilli were resistant in vitro to INH SM PAS.

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