| Multicentric-Multispeciality Clinical Trial on Ambroxol in Korea |
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Yong Chul Han1, Kwan Taick Noh2, Sung Ho Hue3, Sun Young Kim4, Hong Mo Kang5 |
1Department of Internal Medicine, Collegeof Medicine, Seoul National University
2Department of Internal Medicine, Collegeof Medicine, Chung Ang University
3Department of Internal Medicine, Collegeof Medicine, Chung Nam University
4Department of Internal Medicine, Collegeof Medicine, Kyung Hee University
5Department oftolaryngology, Collegeof Medicine, Seoul National University |
| 호흡기 질환에서의 Ambroxol의 임상효과 |
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한용철1, 노관택2, 허성호3, 김선영4, 강홍모5 |
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| Abstract |
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The clinical effect of trans-4 〔(2-amino-3,5, -dibromobenzyl)-amino〕-cyclohexanol hydrochloride(ambroxol) and its effect on lung function were tested in 80 patients(20 patients with acute bronchitis, 20 patients with chronic bronchitis, 20 patients with acute rhinitis and 20 patients with maxillary sinusitis) Among expectorants, there are a considerable number of drugs which have been used without clarification of their pharmacological effects.
Ambroxol, which is a newly developed expectorant, facilitates expectoration by lubricating the expectoration route of sputum, by decreasing the viscosity of sputum through dilution, by increasing mucociliary action, and by secretion of surfactant substances in the lung.
We have studied the expectorant activity of ambroxol and observed the following clinical results.
1) Clinical improvement after treatment with ambroxol was as follows;
cough( 81 %), frequency of sputum( 60%) , volume of sputum(56%). color of sputum(71%) , ease of expectoration(88%) , dyspnea(58%) , severity of rhinorrhea(73%), quality of rhinorrhea (72%), foul odor of rhinorrhea(52%) , nasal stuffiness(77%) , postnasal driP(73%) , and hyposmia (50%).
2) Clinical improvement of pulmonary function test appeared to be somewhat better in acute bronchitis than in chronic brochitis.
3) No remarkable side effect was observed except mild gastrointestinal symptoms, such as indigestion, nausea, vomiting and abdominal pain.
4) Ambroxol was also effective in the treatment of E.N.T. diseases because it stimulates surfactant-like substance production. |
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