| THE MINIMAL INHIBITORY CONCENTRATIONS OF ETHIONAMIDE AND CYCLOSERINE TO
THE TUBERCLE BACILLI |
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Ho Sung Song, Young Pyo Hong, In Sung Jung, Jae Sung Cho |
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Inchon Red Cross Sanatorium |
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| Abstract |
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The minimal inhibitory concentration of ethionamide and cycloserine to H37RV strain and wild strains in Youman's media are increasing stepwise as the incubation time pass. One of the causes of this phenomenon might be owing to the progressive decrease of effective drug concentrations contained in the media. The minimal inhibitory concentrations of ethionamide and cycloserine in H37RV strain are 0.8mcg/ml and 6 mcg/ml respectively. In wide strains, the minimal inhibitory concentrations of ethionamide are ranged from 0.4 mcg/ml to 2.9 mcg/ml in 85 strains, and that of cycloserine are from below 5 mcg/ml to 10 mcg/ml in 106 strains by Youman's media at 10th incubation day. On 4th incubation day microscopy is done, the evidence of growing of cells are judged by cord formed and increased tubercle bacilli, when inocula are made with individually separated cells, As comparing with the turbidity on 10th day, above mentioned microscopic findings are identical, the early detection of resistance to these two drugs seems feasible and practicable. |
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