A Case of the Minimal Change Nephropathy Associated with Small Cell Lung Cancer.

Ko, Kwang Il; Song, Min Keun; Shin, Dong Yeob; Kim, Dong Hyun; Kim, Chan Ho; Han, Chang Hoon; Lee, Sun Min; Choi, Yoon Jung; Kim, Chong Ju

doi:2008.65.1.37

Tuberc Respir Dis > Volume 65(1); 2008 > Article

Case Report

Tuberculosis and Respiratory Diseases 2008;65(1):37-40.
DOI: https://doi.org/10.4046/trd.2008.65.1.37 Published online July 1, 2008.

A Case of the Minimal Change Nephropathy Associated with Small Cell Lung Cancer.

Kwang Il Ko, Min Keun Song, Dong Yeob Shin, Dong Hyun Kim, Chan Ho Kim, Chang Hoon Han, Sun Min Lee, Yoon Jung Choi, Chong Ju Kim

¹Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. kom2d@netsgo.com
²Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

Abstract

Nephrotic syndrome is a relatively rare complication of malignancy. A few cases of nephrotic syndrome accompanying Hodgkin's disease, non-Hodgkin lymphoma, leukemia and other malignancies have been reported since the first case of the nephrotic syndrome associated with extrarenal malignancy was reported in 1922. Hodgkin's disease and solid tumors are known to be the most common malignancies accompanying nephrotic syndrome. The pathologic findings of kidney in patients with Hodgkin's disease commonly show minimal change nephropathy. Membranous glomerulonephropathy is the most common pathologic feature in patients with solid tumors. Although membranous glomerulonephropathy related to small cell lung cancer has rarely been reported in Korea, minimal change nephropathy accompanying small cell lung cancer has never been reported. We present here a case of a 70 year-old male with minimal change nephropathy that was related to small cell lung cancer. We detected small cell lung cancer during the diagnosis work-up of nephrotic syndrome. We suggest that nephrotic syndrome can be a manifestation of underlying malignancy.

Key Words: Small cell lung cancer, Minimal change nephropathy, Nephrotic syndrome