Tuberc Respir Dis > Volume 61(6); 2006 > Article
Tuberculosis and Respiratory Diseases 2006;61(6):591-594.
DOI:    Published online December 1, 2006.
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient.
Yong Soo Baek, Jeong Seon Ryu, Seong Bin Hong, Sung Soo Yoo, Hyung Kwon Yu, Dong Wook Son, Lucia Kim, Hye Sun Kang, Beom Joon Kim, Kyung Hee Lee, Jae Hwa Cho, Young Han Yoon, Seung Min Kwak, Hong Lyeol Lee, Kwang Ho Kim
1Department of Internal Medicine, College of Medicine, Inha University, Incheon, South Korea.
2Department of Pathology, College of Medicine, Inha University, Incheon, South Korea.
3Department of Radiology, College of Medicine, Inha University, Incheon, South Korea.
4Department of Chest Surgery, College of Medicine, Inha University, Incheon, South Korea.
We report a case of pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following adjuvant chemotherapy. A 51-year-old woman with stage IIIA adenocarcinoma received left lower lobe lobectomy in July, 2006. And then combination chemotherapy with paclitaxel and cisplatin was given to the patient. In five days after completion of second cycle of the chemotherapy, she visited emergency room because of general weakness and seizure. Her brain MRI was shown to be no evidence of brain metastasis. Serum sodium, urine and plasma osmolarities were 117mEq/L, 589 and 244mOsm/kg, respectively. She was improved with fluid restriction. Although occurrence of SIADH following chemotherapy is rare, physician should give an attention the potential for development of SIADH in the course of chemotherapyin non-small cell lung cancer patient.
Key Words: Syndrome of inappropriate secretion of antidiuretic hormone, Chemotherapy, Non-small cell lung cancer, Seizure

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