The Clinical Significance of gamma delta T lymphocytes with pleural tuberculosis.

Song, Kwang Seon; Shin, Kye Chul; Kim, Do Hun; Hong, Ae Ra; Kim, Hee Seon; Yong, Suk Joong

doi:1997.44.1.44

Tuberc Respir Dis > Volume 44(1); 1997 > Article

Original Article

Tuberculosis and Respiratory Diseases 1997;44(1):44-51.
DOI: https://doi.org/10.4046/trd.1997.44.1.44 Published online February 1, 1997.

The Clinical Significance of gamma delta T lymphocytes with pleural tuberculosis.

Kwang Seon Song, Kye Chul Shin, Do Hun Kim, Ae Ra Hong, Hee Seon Kim, Suk Joong Yong

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Abstract

BACKGROUND
The changes of the composition in the T-lymphocyte are important as an immunological abnormality in the pathogenesis of tuberculosis. Previously, the second type of TCR dimer(gamma delta T lymphocyte) that did not express CD4 or CD8 molecules was found. In other reports the presence of this type of lymphocytes was increased in the initial stage of tuberculous infections. METHOD: To determine whether there are some differences in the T-lymphocyte subsets in the peripheral blood or pleural effusion among the forty-nine patients were examined T-lymphocyte subset analysis(CD4+T-cell,CD8+ T-cell,gamma delta T-lymphocytes) with anti-Leu4, anti-Leu3a, anti-Leu2a, anti HLA-DR and anti-TCR-gammadelta-1(Becton & Dickinson Co.). RESULTS: The average age of the patients was 50 years old(17-81year). There were 33 males and 16 female patients. patiensts with tuberculosis are 30cases(tuberculous pleurisy 15), lung cancer 12cases(malignant effusion 9) and pneumonia 7cases(parapneumonic effusion 6cases) In T lymphocyte subsets of pleural effusion, helper T lymphocyte(54.6 + 13.8 %) of tuberculous pleurisy was higher than that(36.2 + 25.3 %) of non-tuberculous pleurisy(p= 0.04). The peripheral blood gammadelta T-lymphocytes in tuberculousis was insignificantly higher than non-tuberculous patients(p= 0.24). The peripheral blood gammadelta T-lymphocytes and pleural gammadelta T-lymphocytes in tuberculous pleurisy was insignificantly higher than in non-tuberculous pleurisy(p= 0.16, p= 0.12). CONCLUSION: The percentage of gammadelta T lymphocytes among the total T-lymphocytes is not significantly increased in the peripheral blood or pleural effusion of the pleural tuberculosis. gammadelta T lymphocytes is less useful as a diagnostic method of pleural tuberculosis.

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