| Relationship between cognitive function and arterial blood gases in chronic obstructive pulmonary disease. |
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Young Kyoon Kim, Soon Seog Kwon, Kwan Hyoung Kim, Ki Don Han, Hwa Sik Moon, Jeong Sup Song, Sung Hak Park |
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Department of Internal Medicine, Catholic University Medical College, Seoul, Korea |
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| Abstract |
Background
Cognitive deficit by hypoxia and/or hypercapnia is one of neuropsychological impairments frequently observed in patients with chronic obstructive pulmonary disease (COPD). The degree of cognitive deficit is variable among patients with similar level of hypoxia and/or hypercapnia, although a cause of this individual difference is well not known. COPD can be divided into two characteristic clinical entities including predominant emphysema and predominant bronchitis. This study was designed to evaluate the individual difference in cognitive deficit respond to hypoxia and/ or hypercapnia in patients with COPD.
Methods
Sixteen patients with COPD (9 emphysema-dominant and 7 bronchitis-dominant) participated in this study. On admission arterial blood gas analysis and trail-making B (TMB) test for the evaluation of cognitive funciton were done in all patients. Mean TMB scores and the correlations between TMB scores and arterial blood gases were compared between two clinical groups.
Results
1) Mean TMB scores and arterial blood gases between two clinical groups were not different.
2) There was a tendency to be higher TMB score in hypoxemia, acidemia, and hypercapnia.
However these findings were not statistically significant.
3) In emphysema-dominant group, PaC0 2 was mostly well correlated with TMB score (r=0.693).
4) In bronchitis-dominant group, arterial pH was mostly well correlated with TMB score (r=-0.526).
Conclusion
Our data suggest that the individual difference in cognitive deficit respond to hypoxia and/ or hypercapnia in patients with COPD may be dependent on their clinical entities, and arterial blood gases mostly well correlated with cognitive funciton that may be different according to their clinical entities |
| Key Words:
Cognitive deficit, Arterial blood gases, COPD |
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