The effect of Pyrazinamide on Uric Acid Metabolism

Park, Sung Hak; Min, Wu Sung; Cho, Eui Suk; Back, Nam Jong; Jeong, Jin Wu; Byun, Hae Won

doi:1979.26.1.21

Tuberc Respir Dis > Volume 26(1); 1979 > Article

Original Article

Tuberculosis and Respiratory Diseases 1979;26(1):21-23.
DOI: https://doi.org/10.4046/trd.1979.26.1.21 Published online March 1, 1979.

The effect of Pyrazinamide on Uric Acid Metabolism

Sung Hak Park, Wu Sung Min, Eui Suk Cho, Nam Jong Back, Jin Wu Jeong, Hae Won Byun

Department of Internal Medicine, Catholic Medical College, Seoul, Korea

Pyrazinamiele가 뇨산대사에 미치는 영향

박성학, 민우성, 조의숙, 백남종, 정진우, 변해원

Abstract

It is well known that pyrazinamide inhibits renal excretion of urate, but we could not find clinical gout frequently. Therefore we have studied on the effect of pyrazinamide therapy in a daily dose of 1.5 gm on the urate metabolism in 29 active pulmonary tuberculosis patients (male 17 and female 12), who had normal kidney function and no metabolic disorders. on a regular hospital low-purine diet. 1) The serum concentration of urate were 4.4±1.9 mg/ dl before treatment and 6.5 ±1.7mg/ dl after pyrazinamide therapy for 5 days. 2) The rate of urate clearance to creatinine cleance (C urate/ Ccreatinine) were 0.11 ± 0.07 before treatment and 0.07 ± 0.04 after pyrazinamide therapy for 5 days. 3) The ratio of urine urate to urine creatinine were 0.54± 0.25 before treatment and 0.38± O.l7 after pyrazinamide therapy for 5 days. The mechanism of pyrazamide induced hyperuricemia should be studied further.