Study on Calibration of Definition of Drug Resistance for Secondline Antituberculous Drugs

Kim, Sung Chin; Lee, Kyu Jung; Bai, Gill Han

doi:1979.26.3.1

Tuberc Respir Dis > Volume 26(3); 1979 > Article

Original Article

Tuberculosis and Respiratory Diseases 1979;26(3):1-7.
DOI: https://doi.org/10.4046/trd.1979.26.3.1 Published online September 1, 1979.

Study on Calibration of Definition of Drug Resistance for Secondline Antituberculous Drugs

Sung Chin Kim, Kyu Jung Lee, Gill Han Bai

The Korean Institute of Tuberculosis, KNTA

이차 항결핵 약제의 내성 판정기준 설정에 관한 연구

김성진, 이규정, 배길한

Abstract

An attempt was made to formulate criteria for drug resistence of secondline drugs by the absolute concentration method and the cumulative method which had been set out as cumulative distributions of the results with probably sensitive and probably resistant populations. The criteria of resistance applicable in this laboratory were obtained as follows. Any strain showing growth above 20 or more colonies in concentrations indicated below were classified as resistant to the corresponding drugs Capreomycin 50 μg /ml, Kanamycin 25 μg /ml, Prothionamide 56 μg /ml, Cycloserine 40 μg/ml, Ethambutol 2 μg/ml, Rifampicin 32 μg /ml.