Tuberc Respir Dis > Accepted Articles
DOI: https://doi.org/10.4046/trd.2021.0121    [Accepted]
Published online November 15, 2021.
COPD is not associated with a poor prognosis in COVID-19
Youlim Kim1,2  , Tai Joon An3  , Yong Bum Park4  , Kyungjoo Kim5, Do Yeon Cho6, Chin Kook Rhee5  , Kwang-Ha Yoo1 
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Konkuk University, Seoul, Korea
2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea
3Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal medicine, Yeouido St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal medicine, Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
6Big Data Research Division, Health Insurance Review and Assessment Service, Wonju, Korea
Correspondence:  Kwang-Ha Yoo,
Email: khyou@kuh.ac.kr
Received: 3 August 2021   • Revised: 7 September 2021   • Accepted: 15 October 2021
Abstract
Purpose
The effect of underlying chronic obstructive pulmonary disease (COPD) on coronavirus disease 2019 (COVID-19) during a pandemic is controversial. We set a study to examine the prognosis of COVID-19 according to the underlying COPD.
Material and Methods
COVID-19 patients were assessed using nationwide health insurance data. Comorbidities were evaluated by using the modified Charlson Comorbidity Index (mCCI) which excluded the COPD from conventional CCI scores. Baseline characteristics were assessed. Univariable/multiple logistic and linear regression were used to analyze the effect of variables on clinical outcomes. Ages, sex, mCCI, socioeconomic status, and underlying COPD were selected as variables.
Results
COPD patients showed older age (71.3±11.6 vs. 47.7±19.1, p < 0.001), higher mCCI (2.6±1.9 vs. 0.8±1.3, p < 0.001), and higher mortality (22.9% vs. 3.2%, p < 0.001) than non-COPD patients. The intensive care unit (ICU) admission rate and hospital length of stay (LOS) were not significantly different between the two groups. All variables were associated with mortality in univariate analysis. However, underlying COPD was not associated with mortality unlike other variables in the adjusted analysis. Older ages (odds ratio [OR] 1.12; 95% confidence interval [CI] 1.11–1.14; p < 0.001), male sex (OR 2.29; 95% CI 1.67–3.12; p < 0.001), higher mCCI (OR 1.30; 95% CI 1.20–1.41; p < 0.001), and medical aid insurance (OR 1.55; 95% CI 1.03–2.32; p = 0.035) were associated with mortality.
Conclusions
Underlying COPD was not associated with a poor prognosis in COVID-19.
Key Words: COVID-19, COPD, Prognosis
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ORCID iDs

Youlim Kim
https://orcid.org/0000-0002-1051-0667

Tai Joon An
https://orcid.org/0000-0002-0286-2638

Yong Bum Park
https://orcid.org/0000-0002-5814-6104

Chin Kook Rhee
https://orcid.org/0000-0003-4533-7937

Kwang-Ha Yoo
https://orcid.org/0000-0001-9969-2657

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