Tuberc Respir Dis > Accepted Articles
DOI: https://doi.org/10.4046/trd.2021.0162    [Accepted]
Published online March 8, 2022.
Role of nuclear factor erythroid 2-related factor 2 in chronic obstructive pulmonary disease
Woo Ho Ban1, Chin Kook Rhee2
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea
2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence:  Chin Kook Rhee, Tel: +82 2 2258 6067, Fax: +82 2 599 3589, 
Email: chinkook77@gmail.com
Received: 3 November 2021   • Revised: 22 January 2022   • Accepted: 1 March 2022
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.
Key Words: Chronic obstructive pulmonary disease, nuclear factor erythroid 2-related factor 2, oxidative stress, inflammation, biomarker


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